Ballast / Guides

Working out the day after your GLP-1 shot

Updated 10/21/2026. General fitness information, not medical advice.

Short answer: keep the session, make it smaller. The day or two after your weekly dose, lift the same weights you normally would but do one set fewer of each movement. You keep the habit and most of the training effect, and you are not grinding through a full session on a bad day.

Why shot days feel different

Nausea and fatigue are among the common side effects listed for the weekly GLP-1 medications, and many people notice them most in the day or two after a dose, especially after a dose increase. Appetite is often at its lowest then too, which makes the protein target harder to hit.

Why not just skip?

Muscle responds to weekly volume, and a skipped session is a third or half of a week's training gone. A shorter session at the same weight keeps the signal that tells your body to hold on to muscle. Keeping the weight the same, rather than dropping it, also means next week's progress picks up where it left off.

Practical rules

Ballast does this for you: tell it your shot day and the next sessions shrink automatically, with one tap to run the full workout instead.

Sources

  1. Mozaffarian D, et al.. Nutritional priorities to support GLP-1 therapy for obesity: a joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Am J Lifestyle Med. 2025. doi.org/10.1177/15598276251344827
  2. Schoenfeld BJ, et al.. Dose-response relationship between weekly resistance training volume and increases in muscle mass: a systematic review and meta-analysis. J Sports Sci. 2017;35(11):1073-1082. doi.org/10.1080/02640414.2016.1210197